Le Bonhomme
Pharma
We've been told to say NO to drugs. Bonhomme disagrees. ALL IN psychopharmacology — open-source, thermodynamically rigorous, unapologetically pro-drug in the clinical sense that matters.
FlexAID∆S, From the Terminal
A synthetic interface demo of genetic search, Shannon score collapse, pose election, and validator receipts—not benchmark output or a physical ΔG measurement.
The psychiatric system isn't broken — it was built for a different century. We're building the tools for this one.
Open-source. Thermodynamically rigorous. Unapologetically pro-drug in the clinical sense that matters: every molecule is a hypothesis about biology, and the stigma attached to psychoactives has killed more people than the molecules themselves.
From the statistical mechanics of ligand binding to the social mechanics of harm reduction, the physics is the same: systems seek lower free energy. Our job is to lower the barrier — algorithmically, pharmacologically, politically.
"Drug is ALWAYS an answer — sometimes the only one available."
— @BonhommePharma
What We Build
Flexible molecular docking with a Voronoi contact proxy, Shannon search diagnostics, explicit ensemble-model boundaries, and protocol-defined exact-pose validation.
Explore FlexAID∆S →Entropy-collapse detector for frontier LLM agents. Zero-shot evaluation-awareness and strategic-deception monitoring via the same H = −Σ pᵢ log₂ pᵢ kernel that powers binding and HRV.
Explore Shannon →Scientifically audited FlexAID∆S explainer: GA score collapse, CF-ensemble estimators, tENCoM relative entropy, animated TUI, and strict claim-ready evidence.
Read the docs →Shannon × Music × Molecular, in AR/VR. BPM drives temperature, Crooks cycles, HRV coupling and binding entropy collapse — click to play in-browser.
Launch experience →Multi-platform Apple biofeedback — name coming soon. Real-time HRV entropy → Shannon Collapse Index during guided chair yoga. Shared kernel with FlexAID∆S across Watch, iPhone, TV, Vision Pro.
View on GitHub →Today: Methadone — μ-opioid agonist + NMDA antagonist · OUD maintenance. Rotates every day. Rigorous pharmacology plus entropy-docking commentary. Mechanism over moralising.
Today's drug — Methadone →The periodic table of psychoactive compounds — pharmacological classes, receptor targets and structural families. The reference sheet your professor wouldn't give you.
Open table →The Physics First
∆G = ∆H − T∆S
Every binding event is a thermodynamic equation. Ignoring the entropy term isn't a shortcut — it's a wrong answer. We compute the whole thing.
Apache 2.0, Full Stop
Proprietary docking tools gatekeep science behind paywalls. Drug discovery belongs to everyone. Our code ships under Apache 2.0, reproducible by construction.
Education Over Prohibition
The war on drugs failed the pharmacology exam. Psychoactives are tools with mechanisms — understandable, predictable, teachable. We teach them.
No Black Boxes
ML correlation without mechanism is astrology with better marketing. We use neural networks as a last resort, not a first instinct. First principles, every time.
Louis-Philippe Morency
Built FlexAID∆S because the field needed thermodynamically honest docking and nobody else was going to do it from a basement in Little Burgundy. Main coder on FlexAID∆S, Shannon, ClusterFuck and NRGsuite; benchmark claims stay bound to frozen protocols, elected poses, denominators, and validator receipts. Anti-prohibitionist. Writing a book on housing, organized crime, and harm reduction in Montréal. Shannon entropy and cats.